2003 MAR 11 - (NewsRx.com & NewsRx.net) -- "Manganese-containing superoxide dismutase (MnSOD) is a major detoxifying enzyme that functions in cellular oxygen metabolism by converting O[subscript]2- to H[subscript]2O[subscript]2. A cDNA encoding the chicken MnSOD (cMnSOD) has been isolated from a chicken embryo fibroblast (CEF) cell cDNA library. The cloned cMnSOD is 1102 bp in length with an open reading frame (ORF) of 224 amino acids (aa) that includes a 26 aa 5'-proximal mitochondrial targeting sequence (NITS)," researchers in the United States report.
"The mature 198 aa region of the cMnSOD is highly conserved among various mammalian species. Two cMnSOD mRNA …
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